Receptors 3: Enzyme linked receptors
Last Modified: 2012-11-21
- monomers or dimers (tyrosine kinase)
- no direct G proteins/not serpentine!
(2) it activates other intracellular proteins that are latent enzymes
- NO is membrane soluble but unstable
- works thru activation of soluble GC so the cyclase is the receptor
- Acts in cell it was made in or diffuses to nearby cells
- extracellular (paracrine) first messenger OR
- intraceullar second messenger
- Stimulates GC --> inc cGMP levels
- either work solely with tyrosine residues or serines/threonines
- superfamily: inhibins, activins, bone morphogenic proteins, antimüllerian hormone
- agonist binds to one of the two components of the enzyme
- serine/threonine kinase
- directly phosphorylate and activate cytoplasmic gene regulatoryprotein “SMADs”
- important in cancers
- ligand binds, come together --> dimer
- tyrosine its autophosphorylated at Y sites --> pY
- intracell signalling proteins bind to pY
- SH2,3 proteins are the first to bind
- tyrosines bind to the complex and function as tyrosine kinases
- SH2and SH3 differ in size and specificity from each other. Each in fact constitutes a family structurally related members.
- some have SH2,3 domains
- others may have PLC --> IP3
- some can activate PI3-kinase
- MAPK (small G-proteins)
- Important in signaling cells to survive and grow
PKB helps in cell survival - GOOD
- inactivates the "Bad" protein
- Bad protein normally activates Bcl2 --> cell death
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