- West Virginia School of Osteopathic Medicine
- Pharmacology 101
Last Modified: 2011-06-04
USES: Allergy, motion sickness, sleep aid
TOX: Sedation, anti-muscarinic (avoid in the elderly), anti-alpha adrenergic
TOX: Far less sedating than 1st generation because of dec entry into the CNS
-Relaxes bronchial smooth m. (B2), adverse effect is tachycardia (B1)
**Use during acute exacerbation**
-Adverse effect: tremor and arrhythmia
Narrow TI (cardiotox, neurotox), metabolized by P450, blocks action of adenosine
Can also use in COPD
-Effective only for the prophylaxis of asthma, not affective during an acute attack
**1st line therapy for chronic asthma**
Also used as an antidote for acetaminophen overdose
-Competitively antagonizes endothelin-1 receptors, decreasing pulmonary vascular resistance
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