review of metabolism 1 REVIEW OF METABOLISM Note: There is no quiz on this material but we think it is an important step towards integration of the metabolic pathways you have learned in Units 10- 14. We recommend that you take a large piece of paper and draw a map that shows how the various pathways interconnect. Also review the key regulatory step in each pathway and consider how this afects connected pathways. Lastly consider where in the cel a particular pathway occurs. If connection of two pathways requires pasage across a membrane, review how this is achieved. 1. By means of a diagram, trace the metabolic relationships among the compounds listed below. Try to organize your diagram in such a way as to show the intra- or extra-mitochondrial location of the compounds. ? acetyl CoA ? NAD + , NADH ? ADP ? NADP + , NADPH ? amino acids ? nucleoside diphosphate sugars ? ATP ? (e.g. UDP-glucose) ? carbon dioxide (CO 2 ) ? oxaloacetate (OA) ? citrate ? oxygen (O 2 ) ? cytochromes (cyt) ? pentoses ? faty acids (f.a.) ? phosphate (P i ) ? fructose 6-phosphate (F6P) ? phosphoenol pyruvate (PEP) ? fructose 1, 6-bisphosphate (FBP) ? 3-phosphoglycerate ? glucose 1-phosphate (G1P) ? polypeptides containing Glu ? glucose 6-phosphate (G6P) ? polysacharides (e.g. glycogen) ? glutamate (Glu) ? pyruvate ? glycerol ? ribulose 1,5-bis P ? ?-ketoglutarate (?-KG) ? trioses (e.g. glyceraldehyde 3-P) ? lactate ? uridine triphosphate (UTP) ? malonyl CoA review of metabolism 2 2. Identify broadly those parts of your diagram representing: a. glycolysis and gluconeogenesis b. the TCA cycle c. polysacharide synthesis and degradation d. faty acid synthesis and degradation e. electron transport and oxidative phosphorylation f. the pentose phosphate/phosphogluconate pathway g. utilization of exces amino acids h. the Calvin cycle and the light reactions of photosynthesis 3. Be able to trace on your diagram a route by which: a. TCA cycle intermediates are replenished as they are drawn off for synthetic proceses. b. Amino acids can be converted into: 1) glucose 2) the ribose moiety of nucleotides 3) faty acids c. Glucose can be converted into 1) amino acids 2) ribose review of metabolism 3 4. Indicate at least one reaction in which each of the following coenzymes function: a. coenzyme A (CoA) b. lipoate c. thiamine pyrophosphate (TP) d. nicotinamide adenine dinucleotide (NAD +) e. flavin adenine dinucleotide (FAD) f. biotin g. NADPH Jim Blankenship Microsoft Word - reviewmetabF08. doc
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