September 4th, 2009 Lecture 3 A. Nucleus- largest organelle enclosed by a double-layered membrane that functions in communication between nuclues and pores in the cytoplasm 1. Hutchinson-Gilford Progeria Syndrome a. Defects in lamin A b. Aging disease found in children c. Progeroid disease d. Dominant, Communicational Defect B. Cells are Organized into Tissue 1. Marfan's Syndrome a. Defect in fibrillin (extracellular matrix) in connective tissue b. Causes elongated bones and afects the heart stretching out arteries c. Found anywhere with connective tissue (bones, blood, etc.) d. Dominant, Structural C. Discovery of DNA 1. Griffith discovered transforming a. Heated-S cells + R cells = living cells 2. Carty found DNA by splitting up organelles of heated- S cells 3. Hershey and Chase a. Looked at bacteriophages and what they insert into bacteria 4. Erwin Chargaff a. Found that the percentage of A always equals T and G equals C D. Components of Nucleotide 1. Phosphate Group 2. Sugar Group (deoxyribose or ribose) 3. Nitrogenous Base (Variable nucleoitdes
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