- screening test for fetal lung maturity: lecithin-sphingomyelin (L/S) ratio in amniotic fluid (>2 healthy, 1.5< predictive of NRDS)
-Risk factors: prematurity, maternal diabetes (due to increased fetal insulin), C section delivery (due to decreased fetal glucocorticoids)
Treatment: maternal steroids before birth and surfactant for infant.
Therapeutic supplemental O2 can result in Retinopathy of prematurity, Intraventricular hemorrhage, Bronchopulmonary dysplasia. (RIB)
-autosomal dom disease due to mutations in fibrillin FBN1. Fibrinillin is a component of microfibrils which form a sheath around elastin fibers. abundant in lens, blood vessels, and periosteum.
appearance: tall stature, long limbs, dislocated lenses,, arachnodactyly (long, slender fingers), scoliosis, joint hypermobility, dilated aorta. death mostly due to cardiovascular complications
- Deficiency in homogenistic acid dioxygrnase (AR). Enz necessary for degradation of tyrosine to fumarate
- Homogentisic acid binds to collagen in connective tissues, leading to OA at a young age
-Blue black deposits in sclerae and ear cartilage, black urine when exposed to air due to oxidization, arthralgia
Where do you get Vitamin B12 from?
Vitamin B12 is cobalamin, strictly obtained from the diet, from animal products such as meat, dairy, & fish needed for myelin & DNA synthesis.
This places vegans at risk for dietary deficiency. Your body stores 1,000x daily requirement, so vitamin B12 deficiency develops only after 4-5 years of complete absence of vitamin B12.
-RBC synthesis relies on B12 dependent recycling of folate- deficiency results in megaloblastic anemia. Impaired myelin synthesis in dorsal & lateral columns results in vibration & position sensation loss & ataxic gait.