Table 7-3 Direct Effects of Direct Acting Cholinoceptor Stimulants (Basic and Clinical Pharmacology) Organ Part of Organ Affected Response Eye Sphincter Muscle of Iris Contraction (miosis) Ciliary Muscle Contraction for near vision Heart SA Node Decrease in rate (negative chronotropy) Atria Decrease in contractile strength and decrease in refractory period. AV node Decrease in conduction velocity and increase in refractory period. Ventricles*** Small decrease in contractile strength. Blood Vessels Arteries Dilation (via EDRF) Constriction (High dose direct effect) Veins Dilation (via EDRF) Constriction (High dose direct effect) Lung Bronchial Muscle Contraction (bronchoconstriction) Bronchial Glands Stimulation Gastrointestinal Tract Motility Increase Sphincters Relaxation Secretion Stimulation Urinary Bladder Detrusor Contraction Sphincter Relaxation Glands Sweat, salivary, lacrimal, nasopharyneal. Secretion. ***remember Shlafer saying that the major effect of the parasympathetic branch on the heart is on the heart rate with negligible effects on ventricular contractility. Our CV book also mentions this.
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