Toxicodynamics oF Environmental Carcinogens
- Johns Hopkins University
- Public Health
- Public Health 280.335
- Toxicodynamics oF Environmental Carcinogens
Last Modified: 2011-07-03
Biological: Viruses, Bacteria
Chemical: Inorganic, Organic, Hormones
Normal, Initiated Cell, Prenoplastic lesion, Malignant Tumor, Clinical Cancer
Double Strand Break
Clastogenesis: Chromosomal breaks: loss, gain or rearrangement
Aneuplodization: Gain or loss of chromosome
Mutated proto-oncogene = oncogene
Loss of ability to regulate growth
Most common mutation: p53
Results in altered structure and function
Mutation results in cell proliferation
Promotion: clonal expansion of initiated cells, benign
Progession: evolution of neoplastic phenotype, malignant
Ex: dietary measures
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